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THUNDER™ Total IRAK4 TR-FRET Cell Signaling Assay Kit

2025-05-09

USD$430.00USD$8,809.00

Sandwich TR-FRET immunoassay for semi-quantitative detection of Human Total IRAK4 (Interleukin-1 Receptor-Associated Kinase 4; IPD1; REN64) in cell lysates. Full assay validation can be found in the Technical Data Sheet. Detailed assay protocols are described in the Generic User Manual.

All products are FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

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100 points, 500 points, 2500 points, 5000 points, 10000 points

Degradation of Total IRAK4 by KT-474 in MCF7 cells
Data show that treatment of MCF7 cells with the PROTAC IRAK4 degrader KT-474 degrades total IRAK4 in a concentration-dependent manner.
Degradation of Total IRAK4 by KT-474 in THP-1 cells
Data show that treatment of THP-1 cells with the PROTAC compound KT-474 degrades total IRAK4. In contrast, levels of housekeeping total GAPDH (measured as a control) remain stable.